As lymphoma spreads throughout the body, it can greatly impact the digestive system by crowding the organs that surround the stomach. The increased size of the spleen can cause it to press on the stomach, giving and individual a sudden feeling of fullness after eating only a small amount of food. If the lymphoma is present in the stomach or intestines, a blockage may lead to a loss of appetite as well, accompanied by stomach pain, nausea, and vomiting. Any type of drastic change in appetite that continues for more than a week is never normal, and should be assessed further by your physician.
